논문 보고서

Thesis Reports

귀중한 정보를 얻으려면 연구 리소스를 통해 최신 상태를 유지하세요.

Stay up to date with our research resource for valuable information.

Logo_whit
Kor | Eng
Sort By
Most Recent
Old to New
Last Updated
image

Biochemical and Biophysical Research Communications

image
Structural basis of lactate dehydrogenase A-gossypol complex

Lactate dehydrogenase A (LDHA) is a key enzyme in Warburg’s effect, a characteristic of cancer cells. LDHA is a target of anticancer agents that inhibit the metabolism of cancer cells. Gossypol is a known cancer therapeutic agent that inhibits LDHA by competitive inhibition. However, the mechanisms of inhibition of LDHA by gossypol is unknown. Here, […]

Authors:
Chang Woo Han, Hong Yeoul Kim, Ki-Tae Ha, Mi Suk Jeong, Min Seon Ha, Se Bok Jang, Seyun Cheon See all authors
image

Biochemical and Biophysical Research Communications

image
Structural identification and comprehension of human ALDH1L1-Gossypol complex

The folate metabolism enzyme ALDH1L1 catalyzed 10-formyltetrahydrofolate to tetrahydrofolate and CO2. Non-small cell lung cancer cells (NSCLC) strongly express ALDH1L1. Gossypol binds to an allosteric site and disrupts the folate metabolism by preventing NADP+ binding. The Cryo-EM structures of tetrameric C-terminal aldehyde dehydrogenase human ALDH1L1 complex with gossypol were examined.

Authors:
Chang Woo Han, Han Na Lee, Hong Yeoul Kim, Mi Suk Jeong, Se Bok Jang See all authors

Journal of translational medicine

Modulation of innate immunity related genes resulting in prophylactic antimicrobial and antiviral properties

The innate immunity acts during the early phases of infection and its failure in response to a multilayer network of co-infections is cause of immune system dysregulation. Epidemiological SARS-CoV-2 infections data, show that Influenza Virus (FLU-A-B-C) and Respiratory Syncytial Virus (RSV ) are co-habiting those respiratory traits.

Authors:
2 and Massimo Zollo1, Antonio Polcaro7, Antonio Randazzo4, Carla Zannella6, Chiara Pagliuca1, Franca Oglio2, Luana Izzo4, Luigi Castaldo4, Marco Miceli2, Marica Cozzolino2, Massimiliano Galdiero6, Orazio Bianco2, Paola Salvatore1, Roberta Colicchio1, Roberto Berni Canani2, Veronica Ferrucci1 See all authors
image

Embo Reports

image
Targeting ATP2B1 impairs PI3K/Akt/FOXO signaling and reduces SARS-COV-2 infection and replication

ATP2B1 is a known regulator of calcium (Ca2+) cellular export and homeostasis. Diminished levels of intracellular Ca2+ content have been suggested to impair SARS-CoV-2 replication. Here, we demonstrate that a nontoxic caloxin-derivative compound (PI-7) reduces intracellular Ca2+ levels and impairs SARS-CoV-2 infection. Furthermore, a rare homozygous intronic variant of ATP2B1 is shown to be associated with the severity of COVID-19.

Authors:
Francesca Bibbo, Marco Miceli, Pasqualino de Antonellis, Veronica Ferrucci See all authors
image

Science signalling | Coronavirus

image
Long-chain polyphosphates impair SARS-CoV-2 infection and replication

Inorganic polyphosphates (polyPs) are linear polymers composed of repeated phosphate (PO43−) units linked to-
gether by multiple high-energy phosphoanhydride bonds. In addition to being a source of energy, polyPs have 
cytoprotective and antiviral activities. Here, we investigated the antiviral activities of long-chain polyPs against 
severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection.

Authors:
Dae-Young Kong, Fatemeh Asadzadeh, Laura Marrone, Veronica Ferrucci See all authors